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Early-Age-Onset Colorectal Cancer Screening & Referral Pathways

Colorectal cancer (CRC) rates are rising among adults under 50, especially in California. Too often, younger patients experience delayed or missed diagnoses often leading to worse outcomes.

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Early recognition and timely screening can save lives. As a provider, your role is critical: identify symptoms early, start screening when appropriate, and refer to specialists without delay.

Screening Guidelines at a Glance

Why Use the Early-Age-Onset CRC Symptom Checklist?

Colorectal cancer rates are rising in people under 50, especially here in California. Early detection is key to improving outcomes, but symptoms in younger patients are often missed or dismissed. This checklist helps you quickly identify those at risk so you can recommend timely screening or specialist referral.

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Screen early for any patient who:

  • Presents with symptoms at any age (rectal bleeding, unexplained weight loss, abdominal pain, etc.)

  • Has a family history of colorectal cancer or polyps

  • Has a known hereditary syndrome (e.g., Lynch syndrome, FAP)

  • Has lifestyle risk factors such as smoking, obesity, or heavy alcohol use

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Recommended Tests:

Colonoscopy

FIT (Fecal Immunochemical Test)

Cologuard

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Suggested Age Thresholds:

Begin at 45 for average risk

Begin as early as 21 for high-risk patients

Early-Age-Onset Colorectal Cancer (EAO CRC) Screening
Patient Intake Form

This form is designed for use in primary care and gastroenterology settings to identify early-age-onset colorectal cancer symptoms and risk factors during routine patient intake. Please review the checklist below with the patient and take appropriate screening or referral action as indicated.

Referral Pathways: What to Do When You Spot Red Flags

When a patient under 50 presents with potential colorectal cancer symptoms, time matters.
Early-age-onset cases progress rapidly and are frequently misattributed to benign conditions. As a
provider, your response can directly influence survival outcomes. This guide outlines the best-practice
pathway for timely evaluation, referral, and coordination of care.

 

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Funding for this project was provided by HealtheVoices Impact Fund at the Community Foundation of New Jersey, which was funded by a contribution from Johnson & Johnson.

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